Artificial Intelligence (AI) is reshaping every sector of society — from agriculture and manufacturing to transportation, energy, and healthcare. At Iowa State University, we are embracing this transformation through a Translational AI approach that integrates cutting-edge research with real-world applications across diverse domains, or what we call AI+X. In this talk, I will highlight how Iowa State researchers are working at the intersection of AI and critical application areas, translating their innovations into practice. I will also discuss our comprehensive AI training initiatives designed to reach learners across the spectrum — from AI-novices to AI-aware practitioners to AI-experts — ensuring broad and inclusive access to AI education. Finally, I will share our efforts in developing a strong AI+X student pipeline and fostering an academia-industry nexus to build the next-generation AI workforce for the Midwest and beyond.